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Epigenetic integrity of paternal imprints enhances the developmental potential of androgenetic haploid embryonic stem cells
The use of two inhibitors of Mek1/2 and Gsk3β (2i) promotes the generation of mouse diploid and haploid embryonic stem cells (ESCs) from the inner cell mass of biparental and uniparental blastocysts, respectively. However, a system enabling long-term maintenance of imprints in ESCs has proven challe...
Autores principales: | Zhang, Hongling, Li, Yuanyuan, Ma, Yongjian, Lai, Chongping, Yu, Qian, Shi, Guangyong, Li, Jinsong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Higher Education Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783938/ https://www.ncbi.nlm.nih.gov/pubmed/34865203 http://dx.doi.org/10.1007/s13238-021-00890-3 |
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