Discovery of a dual-action small molecule that improves neuropathological features of Alzheimer’s disease mice

Alzheimer’s disease (AD) is characterized by complex, multifactorial neuropathology, suggesting that small molecules targeting multiple neuropathological factors are likely required to successfully impact clinical progression. Acid sphingomyelinase (ASM) activation has been recognized as an importan...

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Detalles Bibliográficos
Autores principales: Park, Min Hee, Park, Kang Ho, Choi, Byung Jo, Han, Wan Hui, Yoon, Hee Ji, Jung, Hye Yoon, Lee, Jihoon, Song, Im-Sook, Lim, Dong Yu, Choi, Min-Koo, Lee, Yang-Ha, Park, Cheol-Min, Wang, Ming, Jo, Jihoon, Kim, Hee-Jin, Kim, Seung Hyun, Schuchman, Edward H., Jin, Hee Kyung, Bae, Jae-sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784098/
https://www.ncbi.nlm.nih.gov/pubmed/35027452
http://dx.doi.org/10.1073/pnas.2115082119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784098/
https://www.ncbi.nlm.nih.gov/pubmed/35027452
http://dx.doi.org/10.1073/pnas.2115082119

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