Multivalency enables unidirectional switch-like competition between intrinsically disordered proteins

Intrinsically disordered proteins must compete for binding to common regulatory targets to carry out their biological functions. Previously, we showed that the activation domains of two disordered proteins, the transcription factor HIF-1α and its negative regulator CITED2, function as a unidirection...

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Detalles Bibliográficos
Autores principales: Berlow, Rebecca B., Dyson, H. Jane, Wright, Peter E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784115/
https://www.ncbi.nlm.nih.gov/pubmed/35012986
http://dx.doi.org/10.1073/pnas.2117338119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784115/
https://www.ncbi.nlm.nih.gov/pubmed/35012986
http://dx.doi.org/10.1073/pnas.2117338119

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