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Multivalency enables unidirectional switch-like competition between intrinsically disordered proteins
Intrinsically disordered proteins must compete for binding to common regulatory targets to carry out their biological functions. Previously, we showed that the activation domains of two disordered proteins, the transcription factor HIF-1α and its negative regulator CITED2, function as a unidirection...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784115/ https://www.ncbi.nlm.nih.gov/pubmed/35012986 http://dx.doi.org/10.1073/pnas.2117338119 |