Functional communication between IP(3)R and STIM2 at subthreshold stimuli is a critical checkpoint for initiation of SOCE

Stromal interaction molecules, STIM1 and STIM2, sense decreases in the endoplasmic reticulum (ER) [Ca(2+)] ([Ca(2+)](ER)) and cluster in ER–plasma membrane (ER–PM) junctions where they recruit and activate Orai1. While STIM1 responds when [Ca(2+)](ER) is relatively low, STIM2 displays constitutive c...

Descripción completa

Detalles Bibliográficos
Autores principales: Ahmad, Moaz, Ong, Hwei Ling, Saadi, Hassan, Son, Ga-Yeon, Shokatian, Zahra, Terry, Lara E., Trebak, Mohamed, Yule, David I., Ambudkar, Indu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784118/
https://www.ncbi.nlm.nih.gov/pubmed/35022238
http://dx.doi.org/10.1073/pnas.2114928118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784118/
https://www.ncbi.nlm.nih.gov/pubmed/35022238
http://dx.doi.org/10.1073/pnas.2114928118

Ejemplares similares