RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder

Elongating RNA polymerase II (Pol II) can be paused or arrested by a variety of obstacles. These obstacles include DNA lesions, DNA-binding proteins, and small molecules. Hairpin pyrrole-imidazole (Py-Im) polyamides bind to the minor groove of DNA in a sequence-specific manner and induce strong tran...

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Detalles Bibliográficos
Autores principales: Oh, Juntaek, Jia, Tiezheng, Xu, Jun, Chong, Jenny, Dervan, Peter B., Wang, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784135/
https://www.ncbi.nlm.nih.gov/pubmed/35022237
http://dx.doi.org/10.1073/pnas.2114065119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784135/
https://www.ncbi.nlm.nih.gov/pubmed/35022237
http://dx.doi.org/10.1073/pnas.2114065119

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