Genome-wide screens identify specific drivers of mutant hTERT promoters

Cancer-specific hTERT promoter mutations reported in 19% of cancers result in enhanced telomerase activity. Understanding the distinctions between transcriptional regulation of wild-type (WT) and mutant (Mut) hTERT promoters may open up avenues for development of inhibitors which specially block hTE...

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Detalles Bibliográficos
Autores principales: Shanmugam, Raghuvaran, Ozturk, Mert Burak, Low, Joo-Leng, Akincilar, Semih Can, Chua, Joelle Yi Heng, Thangavelu, Matan Thangavelu, Periyasamy, Giridharan, DasGupta, Ramanuj, Tergaonkar, Vinay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784157/
https://www.ncbi.nlm.nih.gov/pubmed/35027447
http://dx.doi.org/10.1073/pnas.2105171119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784157/
https://www.ncbi.nlm.nih.gov/pubmed/35027447
http://dx.doi.org/10.1073/pnas.2105171119

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