The ubiquitin-binding domain of DNA polymerase η directly binds to DNA clamp PCNA and regulates translesion DNA synthesis

DNA polymerase eta (Polη) is a unique translesion DNA synthesis (TLS) enzyme required for the error-free bypass of ultraviolet ray (UV)-induced cyclobutane pyrimidine dimers in DNA. Therefore, its deficiency confers cellular sensitivity to UV radiation and an increased rate of UV-induced mutagenesis...

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Detalles Bibliográficos
Autores principales: Manohar, Kodavati, Khandagale, Prashant, Patel, Shraddheya Kumar, Sahu, Jugal Kishor, Acharya, Narottam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784325/
https://www.ncbi.nlm.nih.gov/pubmed/34929163
http://dx.doi.org/10.1016/j.jbc.2021.101506

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784325/
https://www.ncbi.nlm.nih.gov/pubmed/34929163
http://dx.doi.org/10.1016/j.jbc.2021.101506

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