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The ubiquitin-binding domain of DNA polymerase η directly binds to DNA clamp PCNA and regulates translesion DNA synthesis
DNA polymerase eta (Polη) is a unique translesion DNA synthesis (TLS) enzyme required for the error-free bypass of ultraviolet ray (UV)-induced cyclobutane pyrimidine dimers in DNA. Therefore, its deficiency confers cellular sensitivity to UV radiation and an increased rate of UV-induced mutagenesis...
Autores principales: | Manohar, Kodavati, Khandagale, Prashant, Patel, Shraddheya Kumar, Sahu, Jugal Kishor, Acharya, Narottam |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784325/ https://www.ncbi.nlm.nih.gov/pubmed/34929163 http://dx.doi.org/10.1016/j.jbc.2021.101506 |
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