DROSHA but not DICER is required for human haematopoietic stem cell function

OBJECTIVES: DROSHA and DICER have central roles in the biogenesis of microRNAs (miRNAs). However, we previously showed that in the murine system, DROSHA has an alternate function where it directly recognises and cleaves protein‐coding messenger (m)RNAs and this is critical for safeguarding the pluri...

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Detalles Bibliográficos
Autores principales: Gu, Karen, Walpole, Carina, Gooneratne, Shayarana, Liu, Xin, Haigh, Oscar L, Radford, Kristen J, Chong, Mark MW
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784585/
https://www.ncbi.nlm.nih.gov/pubmed/35106155
http://dx.doi.org/10.1002/cti2.1361

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784585/
https://www.ncbi.nlm.nih.gov/pubmed/35106155
http://dx.doi.org/10.1002/cti2.1361

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