Genome‐wide off‐target analyses of CRISPR/Cas9‐mediated T‐cell receptor engineering in primary human T cells

OBJECTIVES: Exploiting the forces of human T cells for treatment has led to the current paradigm of emerging immunotherapy strategies. Genetic engineering of the T‐cell receptor (TCR) redirects specificity, ablates alloreactivity and brings significant progress and off‐the‐shelf options to emerging...

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Detalles Bibliográficos
Autores principales: Kaeuferle, Theresa, Stief, Tanja A, Canzar, Stefan, Kutlu, Nayad N, Willier, Semjon, Stenger, Dana, Ferrada‐Ernst, Paulina, Habjan, Nicola, Peters, Annika E, Busch, Dirk H, Feuchtinger, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784854/
https://www.ncbi.nlm.nih.gov/pubmed/35106156
http://dx.doi.org/10.1002/cti2.1372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8784854/
https://www.ncbi.nlm.nih.gov/pubmed/35106156
http://dx.doi.org/10.1002/cti2.1372

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