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Immediate induction of varicosities by transverse compression but not uniaxial stretch in axon mechanosensation

Uniaxial stretch is believed to drive diffuse axonal injury (DAI) in mild traumatic brain injury (mTBI). Axonal varicosities are enlarged structures along axonal shafts and represent a hallmark feature of DAI. Here we report that axonal varicosities initiate in vivo immediately after head impact and...

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Detalles Bibliográficos
Autores principales: Sun, Chao, Qi, Lin, Cheng, Yang, Zhao, Yi, Gu, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8785443/
https://www.ncbi.nlm.nih.gov/pubmed/35074017
http://dx.doi.org/10.1186/s40478-022-01309-8