Cargando…

Loss of RPS27a expression regulates the cell cycle, apoptosis, and proliferation via the RPL11-MDM2-p53 pathway in lung adenocarcinoma cells

BACKGROUND: Depletion of certain ribosomal proteins induces p53 activation, which is mediated mainly by ribosomal protein L5 (RPL5) and/or ribosomal protein L11 (RPL11). Therefore, RPL5 and RPL11 may link RPs and p53 activation. Thus, this study aimed to explore whether RPs interact with RPL11 and r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Hongyan, Zhang, Hong, Huang, Guomin, Bing, Zhitong, Xu, Duling, Liu, Jiadi, Luo, Hongtao, An, Xiaoli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8785590/ https://www.ncbi.nlm.nih.gov/pubmed/35073964 http://dx.doi.org/10.1186/s13046-021-02230-z

Ejemplares similares

Ribosomal Proteins RPL37, RPS15 and RPS20 Regulate the Mdm2-p53-MdmX Network
por: Daftuar, Lilyn, et al.
Publicado: (2013)

RPL15 promotes hepatocellular carcinoma progression via regulation of RPs-MDM2-p53 signaling pathway
por: Shi, Rui, et al.
Publicado: (2022)

RPS27a and RPL40, Which Are Produced as Ubiquitin Fusion Proteins, Are Not Essential for p53 Signalling
por: Eastham, Matthew John, et al.
Publicado: (2023)

Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation
por: Zheng, Jiangge, et al.
Publicado: (2015)

RPL34‐AS1–induced RPL34 inhibits cervical cancer cell tumorigenesis via the MDM2‐P53 pathway
por: Zhu, Yuanhang, et al.
Publicado: (2021)

Chidamide and Oxaliplatin Synergistically Inhibit Colorectal Cancer Growth by Regulating the RPS27A-MDM2-P53 Axis
por: Li, Zhaopeng, et al.
Publicado: (2023)

p53-Independent Cell Cycle and Erythroid Differentiation Defects in Murine Embryonic Stem Cells Haploinsufficient for Diamond Blackfan Anemia-Proteins: RPS19 versus RPL5
por: Singh, Sharon A., et al.
Publicado: (2014)

Genomic gain of RRS1 promotes hepatocellular carcinoma through reducing the RPL11-MDM2-p53 signaling
por: Cao, Pengbo, et al.
Publicado: (2021)

Identification of a small-molecule RPL11 mimetic that inhibits tumor growth by targeting MDM2-p53 pathway
por: Wang, Bingwu, et al.
Publicado: (2022)

Ribosomal protein RPL11 haploinsufficiency causes anemia in mice via activation of the RP-MDM2-p53 pathway
por: Franklin, Derek A., et al.
Publicado: (2022)

The RPL/RPS Gene Signature of Melanoma CTCs Associates with Brain Metastasis
por: Bowley, Tetiana Y., et al.
Publicado: (2022)

Correction: p53-Independent Cell Cycle and Erythroid Differentiation Defects in Murine Embryonic Stem Cells Haploinsufficient for Diamond Blackfan Anemia-Proteins: RPS19 versus RPL5
Publicado: (2014)

Primary hematopoietic cells from DBA patients with mutations in RPL11 and RPS19 genes exhibit distinct erythroid phenotype in vitro
por: Moniz, H, et al.
Publicado: (2012)

Olaparib Induces RPL5/RPL11-Dependent p53 Activation via Nucleolar Stress
por: Han, Tao, et al.
Publicado: (2022)

The evolutionary fate of rpl32 and rps16 losses in the Euphorbia schimperi (Euphorbiaceae) plastome
por: Alqahtani, Aldanah A., et al.
Publicado: (2021)

The important role of MDM2, RPL5, and TP53 in mycophenolic acid-induced cleft lip and palate
por: Lin, Yangyang, et al.
Publicado: (2021)

Triptolide interrupts rRNA synthesis and induces the RPL23-MDM2-p53 pathway to repress lung cancer cells
por: Wang, Juan, et al.
Publicado: (2020)

PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway
por: Chen, Hongbo, et al.
Publicado: (2016)

Long noncoding RNA PiHL regulates p53 protein stability through GRWD1/RPL11/MDM2 axis in colorectal cancer
por: Deng, Xuan, et al.
Publicado: (2020)

Effects of Concurrent Exposure to Chronic Restraint-Induced Stress and Total-Body Iron Ion Radiation on Induction of Kidney Injury in Mice
por: Xu, Duling, et al.
Publicado: (2022)

Subfunctionalized expression drives evolutionary retention of ribosomal protein paralogs Rps27 and Rps27l in vertebrates
por: Xu, Adele Francis, et al.
Publicado: (2023)

Scd1 Deficiency in Early Embryos Affects Blastocyst ICM Formation through RPs-Mdm2-p53 Pathway
por: Niu, Huimin, et al.
Publicado: (2023)

Loss of FBXO7 results in a Parkinson's‐like dopaminergic degeneration via an RPL23–MDM2–TP53 pathway
por: Stott, Simon RW, et al.
Publicado: (2019)

Cancer-mutated ribosome protein L22 (RPL22/eL22) suppresses cancer cell survival by blocking p53-MDM2 circuit
por: Cao, Bo, et al.
Publicado: (2017)

PICT1 regulates TP53 via RPL11 and is involved in gastric cancer progression
por: Uchi, R, et al.
Publicado: (2013)

MeCP2 facilitates breast cancer growth via promoting ubiquitination-mediated P53 degradation by inhibiting RPL5/RPL11 transcription
por: Tong, DongDong, et al.
Publicado: (2020)

The value of RPS15 and MRPS27 in ischemic stroke
por: Zhao, Man, et al.
Publicado: (2023)

Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8
por: De Bortoli, Massimiliano, et al.
Publicado: (2006)

Benzimidazoles Downregulate Mdm2 and MdmX and Activate p53 in MdmX Overexpressing Tumor Cells
por: Mrkvová, Zuzana, et al.
Publicado: (2019)

MDM4 expression as an indicator of TP53 reactivation by combined targeting of MDM2 and MDM4 in cancer cells without TP53 mutation
por: Hirose, Mitsuaki, et al.
Publicado: (2014)

Inactivation of ribosomal protein S27-like confers radiosensitivity via the Mdm2-p53 and Mdm2–MRN–ATM axes
por: Zhao, Yongchao, et al.
Publicado: (2018)

MDM2 E3 ligase activity is essential for p53 regulation and cell cycle integrity
por: Chinnam, Meenalakshmi, et al.
Publicado: (2022)

P53/MDM2 Complex-Based Targeted Strategies in Colon Adenocarcinoma
por: Niotis, Athanasios, et al.
Publicado: (2023)

Ribosomal Protein S27/Metallopanstimulin-1 (RPS27) in Glioma—A New Disease Biomarker?
por: Feldheim, Jonas, et al.
Publicado: (2020)

The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p
por: Towers, Christina G., et al.
Publicado: (2015)

Monilophyte mitochondrial rps1 genes carry a unique group II intron that likely originated from an ancient paralog in rpl2
por: Knie, Nils, et al.
Publicado: (2016)

A highly recurrent RPS27 5'UTR mutation in melanoma
por: Dutton-Regester, Ken, et al.
Publicado: (2014)

SIRT7 activates p53 by enhancing PCAF-mediated MDM2 degradation to arrest the cell cycle
por: Lu, Ya-Fei, et al.
Publicado: (2020)

Correction: MDM2 E3 ligase activity is essential for p53 regulation and cell cycle integrity
por: Chinnam, Meenalakshmi, et al.
Publicado: (2022)

Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis s a target, a substrate, and a regulator
por: Xiong, Xiufang, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_664rgiam2g4367rckuqcvue66g