Cargando…

Pharmacological Inhibition of CETP (Cholesteryl Ester Transfer Protein) Increases HDL (High-Density Lipoprotein) That Contains ApoC3 and Other HDL Subspecies Associated With Higher Risk of Coronary Heart Disease

Plasma total HDL (high-density lipoprotein) is a heterogeneous mix of many protein-based subspecies whose functions and associations with coronary heart disease vary. We hypothesize that increasing HDL by CETP (cholesteryl ester transfer protein) inhibition failed to reduce cardiovascular disease ri...

Descripción completa

Detalles Bibliográficos
Autores principales:	Furtado, Jeremy D., Ruotolo, Giacomo, Nicholls, Stephen J., Dullea, Robert, Carvajal-Gonzalez, Santos, Sacks, Frank M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2021
Materias:	Clinical and Population Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8785774/ https://www.ncbi.nlm.nih.gov/pubmed/34937388 http://dx.doi.org/10.1161/ATVBAHA.121.317181

Ejemplares similares

High-Density Lipoprotein (HDL) Particle Subpopulations in Heterozygous Cholesteryl Ester Transfer Protein (CETP) Deficiency: Maintenance of Antioxidative Activity
por: Chantepie, Sandrine, et al.
Publicado: (2012)

CETP (Cholesteryl Ester Transfer Protein) Inhibition With Anacetrapib Decreases Production of Lipoprotein(a) in Mildly Hypercholesterolemic Subjects
por: Thomas, Tiffany, et al.
Publicado: (2017)

ApoE and apoC-III-defined HDL subtypes: a descriptive study of their lecithin cholesterol acyl transferase and cholesteryl ester transfer protein content and activity
por: Amaya-Montoya, Mateo, et al.
Publicado: (2020)

Cholesteryl Ester Transfer Protein (CETP) Polymorphisms Affect mRNA Splicing, HDL Levels, and Sex-Dependent Cardiovascular Risk
por: Papp, Audrey C., et al.
Publicado: (2012)

Cholesteryl ester transfer protein (CETP), HDL capacity of receiving cholesterol and status of inflammatory cytokines in patients with severe heart failure
por: Martinelli, Ana Elisa M., et al.
Publicado: (2018)

Cholesteryl Ester Transfer Protein (CETP) Deficiency and CETP Inhibitors
por: Mabuchi, Hiroshi, et al.
Publicado: (2014)

Sex differences in HDL ApoC-III in American Indian youth
por: Blackett, Piers R, et al.
Publicado: (2012)

Associations of HDL Subspecies Defined by ApoC3 with Non-Alcoholic Fatty Liver Disease: The Multi-Ethnic Study of Atherosclerosis
por: Morze, Jakub, et al.
Publicado: (2020)

Nicotinic Acid Accelerates HDL Cholesteryl Ester Turnover in Obese Insulin-Resistant Dogs
por: Le Bloc'h, Jérôme, et al.
Publicado: (2015)

Atorvastatin and Fenofibrate Increase the Content of Unsaturated Acyl Chains in HDL and Modify In Vivo Kinetics of HDL-Cholesteryl Esters in New Zealand White Rabbits
por: Flores-Castillo, Cristóbal, et al.
Publicado: (2019)

The cholesteryl ester transfer protein (CETP) raises cholesterol levels in the brain
por: Oestereich, Felix, et al.
Publicado: (2022)

Metabolism of PLTP, CETP, and LCAT on multiple HDL sizes using the Orbitrap Fusion Lumos
por: Singh, Sasha A., et al.
Publicado: (2021)

eNOS Activation by HDL Is Impaired in Genetic CETP Deficiency
por: Gomaraschi, Monica, et al.
Publicado: (2014)

Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease
por: Schmidt, Amand F., et al.
Publicado: (2021)

Niacin Reduces Atherosclerosis Development in APOE*3Leiden.CETP Mice Mainly by Reducing NonHDL-Cholesterol
por: Kühnast, Susan, et al.
Publicado: (2013)

HDL-cholesterol concentration in pregnant Chinese Han women of late second trimester associated with genetic variants in CETP, ABCA1, APOC3, and GALNT2
por: Cui, Mingxuan, et al.
Publicado: (2017)

Impact of variants in CETP and apo AI genes on serum HDL cholesterol levels in men and women from the Polish population
por: Włodarczyk, Marta, et al.
Publicado: (2016)

Effect of Selective Androgen Receptor Modulator on Cholesterol Efflux Capacity, Size, and Subspecies of HDL Particles
por: Guo, Wen, et al.
Publicado: (2022)

Association Between Lipids, Lipoproteins Composition of HDL Particles and Triglyceride-Rich Lipoproteins, and LCAT and CETP Activity in Post-renal Transplant Patients
por: Kimak, Elżbieta, et al.
Publicado: (2013)

Current and Emerging Reconstituted HDL-apoA-I and HDL-apoE Approaches to Treat Atherosclerosis
por: Valanti, Eftaxia-Konstantina, et al.
Publicado: (2018)

ApoCIII enrichment in HDL impairs HDL-mediated cholesterol efflux capacity
por: Luo, Mengdie, et al.
Publicado: (2017)

Cholesteryl Ester Transfer Protein (CETP) expression does not affect glucose homeostasis and insulin secretion: studies in human CETP transgenic mice
por: Raposo, Helena F., et al.
Publicado: (2016)

The Current Status of Research on High-Density Lipoproteins (HDL): A Paradigm Shift from HDL Quantity to HDL Quality and HDL Functionality
por: Cho, Kyung-Hyun
Publicado: (2022)

Variants in the CETP gene affect levels of HDL cholesterol by reducing the amount, and not the specific lipid transfer activity, of secreted CETP
por: Ølnes, Åsa Schawlann, et al.
Publicado: (2023)

Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport
por: Niesor, Eric J., et al.
Publicado: (2010)

Human Serum Amyloid a Impaired Structural Stability of High-Density Lipoproteins (HDL) and Apolipoprotein (Apo) A-I and Exacerbated Glycation Susceptibility of ApoA-I and HDL
por: Cho, Kyung-Hyun
Publicado: (2022)

Serum Cholesteryl Ester Transfer Protein (CETP) and Sortilin (SORT) in Patients with Psoriasis with Relation to Systemic Treatment
por: Nowowiejska, Julia, et al.
Publicado: (2022)

The Association of Common SNPs and Haplotypes in CETP Gene with HDL Cholesterol Levels in Latvian Population
por: Radovica, Ilze, et al.
Publicado: (2013)

Nascent HDL (High-Density Lipoprotein) Discs Carry Cholesterol to HDL Spheres: Effects of HDL Particle Remodeling on Cholesterol Efflux
por: Navdaev, Alexei V., et al.
Publicado: (2020)

Effects of the cholesteryl ester transfer protein inhibitor evacetrapib on lipoproteins, apolipoproteins and 24-h ambulatory blood pressure in healthy adults
por: Suico, Jeffrey G, et al.
Publicado: (2014)

Subfractions of high-density lipoprotein (HDL) and dysfunctional HDL in chronic kidney disease patients
por: Rysz-Górzyńska, Magdalena, et al.
Publicado: (2016)

The Roles of ApoC-III on the Metabolism of Triglyceride-Rich Lipoproteins in Humans
por: Borén, Jan, et al.
Publicado: (2020)

Antisense oligonucleotide inhibition of cholesteryl ester transfer protein enhances RCT in hyperlipidemic, CETP transgenic, LDLr(−/−) mice
por: Bell, Thomas A., et al.
Publicado: (2013)

The Presence of Cholesteryl Ester Transfer Protein (CETP) in Endothelial Cells Generates Vascular Oxidative Stress and Endothelial Dysfunction
por: Wanschel, Amarylis C. B. A., et al.
Publicado: (2021)

ApoA-I/A-II-HDL positively associates with apoB-lipoproteins as a potential atherogenic indicator
por: Kido, Toshimi, et al.
Publicado: (2017)

Segregation of LIPG, CETP, and GALNT2 Mutations in Caucasian Families with Extremely High HDL Cholesterol
por: Tietjen, Ian, et al.
Publicado: (2012)

HDL surface lipids mediate CETP binding as revealed by electron microscopy and molecular dynamics simulation
por: Zhang, Meng, et al.
Publicado: (2015)

Fine mapping the CETP region reveals a common intronic insertion associated to HDL-C
por: van Leeuwen, Elisabeth M, et al.
Publicado: (2015)

The lipid substrate preference of CETP controls the biochemical properties of HDL in fat/cholesterol-fed hamsters
por: Morton, Richard E., et al.
Publicado: (2021)

Association of Human Cholesteryl Ester Transfer Protein-TaqI Polymorphisms with Serum HDL Cholesterol Levels in a Normolipemic Japanese Rural Population
por: Chen, Jianguo, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_7vumvc4vs4pbjanhchueagk253