Reduced mitochondria membrane potential and lysosomal acidification are associated with decreased oligomeric Aβ degradation induced by hyperglycemia: A study of mixed glia cultures

Diabetes is a risk factor for Alzheimer’s disease (AD), a chronic neurodegenerative disease. We and others have shown prediabetes, including hyperglycemia and obesity induced by high fat and high sucrose diets, is associated with exacerbated amyloid beta (Aβ) accumulation and cognitive impairment in...

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Detalles Bibliográficos
Autores principales: Huang, Yung-Cheng, Hsu, Shu-Meng, Shie, Feng-Shiun, Shiao, Young-Ji, Chao, Li-Jung, Chen, Hui-Wen, Yao, Heng-Hsiang, Chien, Meng An, Lin, Chung-Chih, Tsay, Huey-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786178/
https://www.ncbi.nlm.nih.gov/pubmed/35073330
http://dx.doi.org/10.1371/journal.pone.0260966

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786178/
https://www.ncbi.nlm.nih.gov/pubmed/35073330
http://dx.doi.org/10.1371/journal.pone.0260966

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