Selection analysis identifies unusual clustered mutational changes in Omicron lineage BA.1 that likely impact Spike function

Among the 30 non-synonymous nucleotide substitutions in the Omicron S-gene are 13 that have only rarely been seen in other SARS-CoV-2 sequences. These mutations cluster within three functionally important regions of the S-gene at sites that will likely impact (i) interactions between subunits of the...

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Detalles Bibliográficos
Autores principales: Martin, Darren P, Lytras, Spyros, Lucaci, Alexander G, Maier, Wolfgang, Grüning, Björn, Shank, Stephen D, Weaver, Steven, MacLean, Oscar A, Orton, Richard J, Lemey, Philippe, Boni, Maciej F, Tegally, Houriiyah, Harkins, Gordon, Scheepers, Cathrine, Bhiman, Jinal N, Everatt, Josie, Amoako, Daniel G, San, James Emmanuel, Giandhari, Jennifer, Sigal, Alex, Williamson, Carolyn, Hsiao, Nei-yuan, von Gottberg, Anne, De Klerk, Arne, Shafer, Robert W, Robertson, David L, Wilkinson, Robert J, Sewell, B Trevor, Lessells, Richard, Nekrutenko, Anton, Greaney, Allison J., Starr, Tyler N., Bloom, Jesse D., Murrell, Ben, Wilkinson, Eduan, Gupta, Ravindra K, de Oliveira, Tulio, Kosakovsky Pond, Sergei L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786225/
https://www.ncbi.nlm.nih.gov/pubmed/35075456
http://dx.doi.org/10.1101/2022.01.14.476382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786225/
https://www.ncbi.nlm.nih.gov/pubmed/35075456
http://dx.doi.org/10.1101/2022.01.14.476382

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