Cryo-EM structure of Mycobacterium tuberculosis 50S ribosomal subunit bound with clarithromycin reveals dynamic and specific interactions with macrolides

Tuberculosis (TB) is the leading infectious disease caused by Mycobacterium tuberculosis (Mtb). Clarithromycin (CTY), an analog of erythromycin (ERY), is more potent against multidrug-resistance (MDR) TB. ERY and CTY were previously reported to bind to the nascent polypeptide exit tunnel (NPET) near...

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Detalles Bibliográficos
Autores principales: Zhang, Wen, Li, ZhiFei, Sun, Yufan, Cui, Peng, Liang, Jianhua, Xing, Qinghe, Wu, Jing, Xu, Yanhui, Zhang, Wenhong, Zhang, Ying, He, Lin, Gao, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Antimicrobial Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786254/
https://www.ncbi.nlm.nih.gov/pubmed/34935599
http://dx.doi.org/10.1080/22221751.2021.2022439

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786254/
https://www.ncbi.nlm.nih.gov/pubmed/34935599
http://dx.doi.org/10.1080/22221751.2021.2022439

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