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New tools for automated cryo-EM single-particle analysis in RELION-4.0

We describe new tools for the processing of electron cryo-microscopy (cryo-EM) images in the fourth major release of the RELION software. In particular, we introduce VDAM, a variable-metric gradient descent algorithm with adaptive moments estimation, for image refinement; a convolutional neural netw...

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Detalles Bibliográficos
Autores principales:	Kimanius, Dari, Dong, Liyi, Sharov, Grigory, Nakane, Takanori, Scheres, Sjors H. W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2021
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786306/ https://www.ncbi.nlm.nih.gov/pubmed/34783343 http://dx.doi.org/10.1042/BCJ20210708

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