Polyunsaturated fatty acids inhibit a pentameric ligand-gated ion channel through one of two binding sites

Polyunsaturated fatty acids (PUFAs) inhibit pentameric ligand-gated ion channels (pLGICs) but the mechanism of inhibition is not well understood. The PUFA, docosahexaenoic acid (DHA), inhibits agonist responses of the pLGIC, ELIC, more effectively than palmitic acid, similar to the effects observed...

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Detalles Bibliográficos
Autores principales: Dietzen, Noah M, Arcario, Mark J, Chen, Lawrence J, Petroff, John T, Moreland, K Trent, Krishnan, Kathiresan, Brannigan, Grace, Covey, Douglas F, Cheng, Wayland WL
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786314/
https://www.ncbi.nlm.nih.gov/pubmed/34982031
http://dx.doi.org/10.7554/eLife.74306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786314/
https://www.ncbi.nlm.nih.gov/pubmed/34982031
http://dx.doi.org/10.7554/eLife.74306

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