Cargando…

Polyunsaturated fatty acids inhibit a pentameric ligand-gated ion channel through one of two binding sites

Polyunsaturated fatty acids (PUFAs) inhibit pentameric ligand-gated ion channels (pLGICs) but the mechanism of inhibition is not well understood. The PUFA, docosahexaenoic acid (DHA), inhibits agonist responses of the pLGIC, ELIC, more effectively than palmitic acid, similar to the effects observed...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dietzen, Noah M, Arcario, Mark J, Chen, Lawrence J, Petroff, John T, Moreland, K Trent, Krishnan, Kathiresan, Brannigan, Grace, Covey, Douglas F, Cheng, Wayland WL
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786314/ https://www.ncbi.nlm.nih.gov/pubmed/34982031 http://dx.doi.org/10.7554/eLife.74306

Ejemplares similares

Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation
por: Petroff, John T., et al.
Publicado: (2022)

Druggable Lipid Binding Sites in Pentameric Ligand-Gated Ion Channels and Transient Receptor Potential Channels
por: Cheng, Wayland W. L., et al.
Publicado: (2022)

Direct binding of phosphatidylglycerol at specific sites modulates desensitization of a ligand-gated ion channel
por: Tong, Ailing, et al.
Publicado: (2019)

Ligand Activation of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC
por: Zimmermann, Iwan, et al.
Publicado: (2011)

Signal Transduction Pathways in the Pentameric Ligand-Gated Ion Channels
por: Mowrey, David, et al.
Publicado: (2013)

Acyl chain asymmetry and polyunsaturation of brain phospholipids facilitate membrane vesiculation without leakage
por: Manni, Marco M, et al.
Publicado: (2018)

Evolution of Pentameric Ligand-Gated Ion Channels: Pro-Loop Receptors
por: Jaiteh, Mariama, et al.
Publicado: (2016)

Chasing the open-state structure of pentameric ligand-gated ion channels
por: Gonzalez-Gutierrez, Giovanni, et al.
Publicado: (2017)

Molecular Mingling: Multimodal Predictions of Ligand Promiscuity in Pentameric Ligand-Gated Ion Channels
por: Koniuszewski, Filip, et al.
Publicado: (2022)

Site-Directed Spin Labeling Reveals Pentameric Ligand-Gated Ion Channel Gating Motions
por: Dellisanti, Cosma D., et al.
Publicado: (2013)

Molecular Simulations of Hydrophobic Gating of Pentameric Ligand Gated Ion Channels: Insights into Water and Ions
por: Rao, Shanlin, et al.
Publicado: (2021)

Inhibition of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC by Divalent Cations
por: Zimmermann, Iwan, et al.
Publicado: (2012)

Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels
por: Sauguet, Ludovic, et al.
Publicado: (2013)

Allosteric regulation of pentameric ligand-gated ion channels: An emerging mechanistic perspective
por: Taly, Antoine, et al.
Publicado: (2014)

Signal Transduction at the Domain Interface of Prokaryotic Pentameric Ligand-Gated Ion Channels
por: Bertozzi, Carlo, et al.
Publicado: (2016)

Pentameric Ligand-Gated Ion Channels as Pharmacological Targets Against Chronic Pain
por: Lara, César O., et al.
Publicado: (2020)

The gating cycle of a K(+) channel at atomic resolution
por: Cuello, Luis G, et al.
Publicado: (2017)

Regulation of Eag1 gating by its intracellular domains
por: Whicher, Jonathan R, et al.
Publicado: (2019)

Molecular mechanisms of gating in the calcium-activated chloride channel bestrophin
por: Miller, Alexandria N, et al.
Publicado: (2019)

Crystal structure of a natural light-gated anion channelrhodopsin
por: Li, Hai, et al.
Publicado: (2019)

Un-gating and allosteric modulation of a pentameric ligand-gated ion channel captured by molecular dynamics
por: Martin, Nicolas E, et al.
Publicado: (2017)

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling
por: Nachtergaele, Sigrid, et al.
Publicado: (2013)

Structural insights into the Ca(2+)-dependent gating of the human mitochondrial calcium uniporter
por: Wang, Yan, et al.
Publicado: (2020)

Structural Basis for Xenon Inhibition in a Cationic Pentameric Ligand-Gated Ion Channel
por: Sauguet, Ludovic, et al.
Publicado: (2016)

Correction: Signal Transduction at the Domain Interface of Prokaryotic Pentameric Ligand-Gated Ion Channels
Publicado: (2016)

A chimeric prokaryotic pentameric ligand–gated channel reveals distinct pathways of activation
por: Schmandt, Nicolaus, et al.
Publicado: (2015)

Molecular basis for convergent evolution of glutamate recognition by pentameric ligand-gated ion channels
por: Lynagh, Timothy, et al.
Publicado: (2015)

Recent Insight into Lipid Binding and Lipid Modulation of Pentameric Ligand-Gated Ion Channels
por: Ananchenko, Anna, et al.
Publicado: (2022)

Origin of acetylcholine antagonism in ELIC, a bacterial pentameric ligand-gated ion channel
por: Slobodyanyuk, Mykhaylo, et al.
Publicado: (2022)

Divergent Cl(-) and H(+) pathways underlie transport coupling and gating in CLC exchangers and channels
por: Leisle, Lilia, et al.
Publicado: (2020)

Tandem riboswitches form a natural Boolean logic gate to control purine metabolism in bacteria
por: Sherlock, Madeline E, et al.
Publicado: (2018)

McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation
por: Hajdusits, Bence, et al.
Publicado: (2021)

Ligand-induced shifts in conformational ensembles that describe transcriptional activation
por: Khan, Sabab Hasan, et al.
Publicado: (2022)

Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine
por: Pan, Jianjun, et al.
Publicado: (2012)

Trapping of ivermectin by a pentameric ligand-gated ion channel upon open-to-closed isomerization
por: Degani-Katzav, Nurit, et al.
Publicado: (2017)

Ligand modulation of sidechain dynamics in a wild-type human GPCR
por: Clark, Lindsay D, et al.
Publicado: (2017)

Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPARγ
por: Shang, Jinsai, et al.
Publicado: (2018)

Molecular basis of ligand-dependent Nurr1-RXRα activation
por: Yu, Xiaoyu, et al.
Publicado: (2023)

Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor
por: Livingston, Kathryn E, et al.
Publicado: (2018)

A potent voltage-gated calcium channel inhibitor engineered from a nanobody targeted to auxiliary Ca(V)β subunits
por: Morgenstern, Travis J, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_65hjbrjb81l24uhf6p7dchefu1