Fc-based Duokines: dual-acting costimulatory molecules comprising TNFSF ligands in the single-chain format fused to a heterodimerizing Fc (scDk-Fc)

Targeting costimulatory receptors of the tumor necrosis factor superfamily (TNFSF) to activate T-cells and promote anti-tumor T-cell function have emerged as a promising strategy in cancer immunotherapy. Previous studies have shown that combining two different members of the TNFSF resulted in dual-a...

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Detalles Bibliográficos
Autores principales: Aschmoneit, Nadine, Kocher, Katharina, Siegemund, Martin, Lutz, Martina S., Kühl, Lennart, Seifert, Oliver, Kontermann, Roland E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786347/
https://www.ncbi.nlm.nih.gov/pubmed/35083097
http://dx.doi.org/10.1080/2162402X.2022.2028961

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786347/
https://www.ncbi.nlm.nih.gov/pubmed/35083097
http://dx.doi.org/10.1080/2162402X.2022.2028961

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