Elimination of Aicardi–Goutières syndrome protein SAMHD1 activates cellular innate immunity and suppresses SARS-CoV-2 replication

The lack of antiviral innate immune responses during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is characterized by limited production of interferons (IFNs). One protein associated with Aicardi–Goutières syndrome, SAMHD1, has been shown to negatively regulate the IFN-1 s...

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Detalles Bibliográficos
Autores principales: Oo, Adrian, Zandi, Keivan, Shepard, Caitlin, Bassit, Leda C., Musall, Katie, Goh, Shu Ling, Cho, Young-Jae, Kim, Dong-Hyun, Schinazi, Raymond F., Kim, Baek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786443/
https://www.ncbi.nlm.nih.gov/pubmed/35085552
http://dx.doi.org/10.1016/j.jbc.2022.101635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786443/
https://www.ncbi.nlm.nih.gov/pubmed/35085552
http://dx.doi.org/10.1016/j.jbc.2022.101635

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