miR-193a-3p increases glycolysis under hypoxia by facilitating Akt phosphorylation and PFKFB3 activation in human macrophages

Human macrophages infiltrating hypoxic regions alter their metabolism, because oxygen becomes limited. Increased glycolysis is one of the most common cellular adaptations to hypoxia and mostly is regulated via hypoxia-inducible factor (HIF) and RAC-alpha serine/threonine–protein kinase (Akt) signali...

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Detalles Bibliográficos
Autores principales: Fuhrmann, Dominik C., Brüne, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786749/
https://www.ncbi.nlm.nih.gov/pubmed/35072776
http://dx.doi.org/10.1007/s00018-022-04146-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786749/
https://www.ncbi.nlm.nih.gov/pubmed/35072776
http://dx.doi.org/10.1007/s00018-022-04146-z

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