Sex-Stratified Single-Cell RNA-Seq Analysis Identifies Sex-Specific and Cell Type-Specific Transcriptional Responses in Alzheimer’s Disease Across Two Brain Regions

Alzheimer’s disease (AD) is a pervasive neurodegenerative disorder that disproportionately affects women. Since neural anatomy and disease pathophysiology differ by sex, investigating sex-specific mechanisms in AD pathophysiology can inform new therapeutic approaches for both sexes. Previous bulk hu...

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Detalles Bibliográficos
Autores principales: Belonwu, Stella A., Li, Yaqiao, Bunis, Daniel, Rao, Arjun Arkal, Solsberg, Caroline Warly, Tang, Alice, Fragiadakis, Gabriela K., Dubal, Dena B., Oskotsky, Tomiko, Sirota, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786804/
https://www.ncbi.nlm.nih.gov/pubmed/34669146
http://dx.doi.org/10.1007/s12035-021-02591-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786804/
https://www.ncbi.nlm.nih.gov/pubmed/34669146
http://dx.doi.org/10.1007/s12035-021-02591-8

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