Flanking sequences influence the activity of TET1 and TET2 methylcytosine dioxygenases and affect genomic 5hmC patterns

TET dioxygenases convert 5-methylcytosine (5mC) preferentially in a CpG context into 5-hydroxymethylcytosine (5hmC) and higher oxidized forms, thereby initiating DNA demethylation, but details regarding the effects of the DNA sequences flanking the target 5mC site on TET activity are unknown. We inv...

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Detalles Bibliográficos
Autores principales: Adam, Sabrina, Bräcker, Julia, Klingel, Viviane, Osteresch, Bernd, Radde, Nicole E., Brockmeyer, Jens, Bashtrykov, Pavel, Jeltsch, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786823/
https://www.ncbi.nlm.nih.gov/pubmed/35075236
http://dx.doi.org/10.1038/s42003-022-03033-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786823/
https://www.ncbi.nlm.nih.gov/pubmed/35075236
http://dx.doi.org/10.1038/s42003-022-03033-4

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