Cargando…

Impact of hemolysis on multi-OMIC pancreatic biomarker discovery to derisk biomarker development in precision medicine studies

Cancer biomarker discovery is critically dependent on the integrity of biofluid and tissue samples acquired from study participants. Multi-omic profiling of candidate protein, lipid, and metabolite biomarkers is confounded by timing and fasting status of sample collection, participant demographics a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Searfoss, Richard, Shah, Punit, Ofori-Mensa, Kennedy, Bussberg, Valerie, Tolstikov, Vladimir, Greenwood, Bennett, Li, Hongyan, Richardson, Kris, Miller, Gregory M., DeCicco, Corinne, Granger, Elder, Rodrigues, Leonardo O., Grund, Eric M., Moser, A. James, Sarangarajan, Rangaprasad, Narain, Niven R., Kiebish, Michael A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786830/ https://www.ncbi.nlm.nih.gov/pubmed/35075163 http://dx.doi.org/10.1038/s41598-022-05152-8

Ejemplares similares

Current Status of Metabolomic Biomarker Discovery: Impact of Study Design and Demographic Characteristics
por: Tolstikov, Vladimir, et al.
Publicado: (2020)

Ethnic Prevalence of Angiotensin-Converting Enzyme Deletion (D) Polymorphism and COVID-19 Risk: Rationale for Use of Angiotensin-Converting Enzyme Inhibitors/Angiotensin Receptor Blockers
por: Sarangarajan, Rangaprasad, et al.
Publicado: (2020)

OMRT-13. Delivery of Ubidecarenone (BPM 31510) to mitochondria effectuates metabolic reprogramming and redox activated apoptosis in Glioblastoma
por: Sarangarajan, Rangaprasad, et al.
Publicado: (2021)

Metabolomic effects of androgen deprivation therapy treatment for prostate cancer
por: Chi, Jen‐Tsan, et al.
Publicado: (2020)

Integrated Metabolomics Assessment of Human Dried Blood Spots and Urine Strips
por: Drolet, Jeremy, et al.
Publicado: (2017)

Multi-omic serum biomarkers for prognosis of disease progression in prostate cancer
por: Kiebish, Michael A., et al.
Publicado: (2020)

Dynamic and temporal assessment of human dried blood spot MS/MS(ALL) shotgun lipidomics analysis
por: Gao, Fei, et al.
Publicado: (2017)

Genomic alterations of Tenascin C in highly aggressive prostate cancer: a meta-analysis
por: Mishra, Prachi, et al.
Publicado: (2019)

Comparative analysis of differentially abundant proteins quantified by LC–MS/MS between flash frozen and laser microdissected OCT-embedded breast tumor samples
por: Sturtz, Lori A., et al.
Publicado: (2020)

Monoacylglycerol Analysis Using MS/MS(ALL) Quadruple Time of Flight Mass Spectrometry
por: Gao, Fei, et al.
Publicado: (2016)

Divergence in the metabolome between natural aging and Alzheimer’s disease
por: Hunsberger, Holly C., et al.
Publicado: (2020)

Author Correction: Divergence in the metabolome between natural aging and Alzheimer’s disease
por: Hunsberger, Holly C., et al.
Publicado: (2020)

Chronic stress and antidepressant treatment alter purine metabolism and beta oxidation within mouse brain and serum
por: Hamilton, Peter J., et al.
Publicado: (2020)

Hypothesis-Agnostic Network-Based Analysis of Real-World Data Suggests Ondansetron is Associated with Lower COVID-19 Any Cause Mortality
por: Miller, Gregory M., et al.
Publicado: (2022)

Transplantation of Brown Adipose Tissue with the Ability of Converting Omega-6 to Omega-3 Polyunsaturated Fatty Acids Counteracts High-Fat-Induced Metabolic Abnormalities in Mice
por: Tsuji, Tadataka, et al.
Publicado: (2022)

Older adults with sarcopenia have distinct skeletal muscle phosphodiester, phosphocreatine, and phospholipid profiles
por: Hinkley, James Matthew, et al.
Publicado: (2020)

Clinical utility of a serum biomarker panel in distinguishing prostate cancer from benign prostate hyperplasia
por: Kiebish, Michael A., et al.
Publicado: (2021)

Dysregulation of the calcium handling protein, CCDC47, is associated with diabetic cardiomyopathy
por: Thapa, Khampaseuth, et al.
Publicado: (2018)

Perturbation of the yeast mitochondrial lipidome and associated membrane proteins following heterologous expression of Artemia-ANT
por: Chen, Emily, et al.
Publicado: (2018)

Type 2 myocardial infarction and myocardial injury: eligibility for novel medical therapy to derisk clinical trials
por: Sykes, Robert, et al.
Publicado: (2021)

New In Vitro Interaction-Parasite Reduction Ratio Assay for Early Derisk in Clinical Development of Antimalarial Combinations
por: Wicha, Sebastian G., et al.
Publicado: (2022)

High levels of ubidecarenone (oxidized CoQ(10)) delivered using a drug-lipid conjugate nanodispersion (BPM31510) differentially affect redox status and growth in malignant glioma versus non-tumor cells
por: Sun, Jiaxin, et al.
Publicado: (2020)

The Impact of Hemolysis on Cell-Free microRNA Biomarkers
por: Kirschner, Michaela B., et al.
Publicado: (2013)

Identification of Filamin-A and -B as potential biomarkers for prostate cancer
por: Narain, Niven R, et al.
Publicado: (2016)

ScreenDMT reveals linoleic acid diols replicably associate with BMI and stimulate adipocyte calcium fluxes
por: Dreyfuss, Jonathan M., et al.
Publicado: (2023)

Elevated levels of mitochondrial CoQ(10) induce ROS-mediated apoptosis in pancreatic cancer
por: Dadali, Tulin, et al.
Publicado: (2021)

Ubc1 turnover contributes to the spindle assembly checkpoint in Saccharomyces cerevisiae
por: Arsenault, Heather E, et al.
Publicado: (2021)

Hsp90β knockdown in DIO mice reverses insulin resistance and improves glucose tolerance
por: Jing, Enxuan, et al.
Publicado: (2018)

Doppler velocimetry of the orbital arteries in patients with sickle cell anemia: relationship with biomarkers of hemolysis
por: Ferrão, Thiago de Oliveira, et al.
Publicado: (2017)

Hemolysis, icterus and lipemia interfere with the determination of two oxidative stress biomarkers in canine serum
por: Perez-Montero, B., et al.
Publicado: (2023)

Intrinsic Properties of Brown and White Adipocytes Have Differential Effects on Macrophage Inflammatory Responses
por: Dowal, Louisa, et al.
Publicado: (2017)

TriHy: teaching an MA TESOL class face-to-face, synchronously online, and asynchronously online
por: Porter-Szucs, Ildiko, et al.
Publicado: (2022)

Skeletal Muscle Energetics and Mitochondrial Function Are Impaired Following 10 Days of Bed Rest in Older Adults
por: Standley, Robert A, et al.
Publicado: (2020)

Carboxyhemoglobin, a reliable diagnosis biomarker for hemolysis in intensive care unit: a retrospective study
por: Hariri, Geoffroy, et al.
Publicado: (2021)

Prognostic value of the hemolysis index in patients with significant hemolysis
por: Cortés, Diego O, et al.
Publicado: (2015)

Detection of Early-Stage Pancreatic Ductal Adenocarcinoma From Blood Samples: Results of a Multiplex Biomarker Signature Validation Study
por: Brand, Randall E., et al.
Publicado: (2022)

The Next Frontier: Translational Development of Ubiquitination, SUMOylation, and NEDDylation in Cancer
por: Pellegrino, Nicole E., et al.
Publicado: (2022)

Cyclomodulins and Hemolysis in E. coli as Potential Low-Cost Non-Invasive Biomarkers for Colorectal Cancer Screening
por: Mezerová, Kristýna, et al.
Publicado: (2021)

8-Isoprostane: A salivary oxidative stress biomarker for oral submucous fibrosis and oral squamous cell carcinoma
por: Meera, S, et al.
Publicado: (2020)

MECHANISM OF HEMOLYSIS BY COMPLEMENT : I. COMPLEMENT FIXATION AS AN ESSENTIAL PRELIMINARY TO HEMOLYSIS.
por: Eagle, Harry, et al.
Publicado: (1929)

Cannot write session to /tmp/vufind_sessions/sess_obu76beon8hsdmc6gfq662hum0