An oncogenic splice variant of PDGFRα in adult glioblastoma as a therapeutic target for selective CDK4/6 inhibitors

Understanding human genome alterations is necessary to optimize genome-based cancer therapeutics. However, some newly discovered mutations remain as variants of unknown significance (VUS). Here, the mutation c.1403A > G in exon 10 of the platelet-derived growth factor receptor-alpha (PDGFRA) gene...

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Detalles Bibliográficos
Autores principales: Hamada, Taiji, Akahane, Toshiaki, Yokoyama, Seiya, Higa, Nayuta, Kirishima, Mari, Matsuo, Kei, Shimokawa, Michiko, Yoshimoto, Koji, Tanimoto, Akihide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786844/
https://www.ncbi.nlm.nih.gov/pubmed/35075231
http://dx.doi.org/10.1038/s41598-022-05391-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786844/
https://www.ncbi.nlm.nih.gov/pubmed/35075231
http://dx.doi.org/10.1038/s41598-022-05391-9

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