MicroRNA-181a–2–3p shuttled by mesenchymal stem cell-secreted extracellular vesicles inhibits oxidative stress in Parkinson’s disease by inhibiting EGR1 and NOX4

The current study investigated the physiological mechanisms by which extracellular vesicle (EV)-encapsulated miR-181a–2–3p derived from mesenchymal stem cells (MSCs) might mediate oxidative stress (OS) in Parkinson’s disease (PD). First, 6-hydroxydopamine (6-OHDA)-induced PD cell and mouse models we...

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Detalles Bibliográficos
Autores principales: Ma, Jianjun, Shi, Xiaoxue, Li, Mingjian, Chen, Siyuan, Gu, Qi, Zheng, Jinhua, Li, Dongsheng, Wu, Shaopu, Yang, Hongqi, Li, Xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786891/
https://www.ncbi.nlm.nih.gov/pubmed/35075150
http://dx.doi.org/10.1038/s41420-022-00823-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786891/
https://www.ncbi.nlm.nih.gov/pubmed/35075150
http://dx.doi.org/10.1038/s41420-022-00823-x

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