ER stress-induced cell death proceeds independently of the TRAIL-R2 signaling axis in pancreatic β cells

Prolonged ER stress and the associated unfolded protein response (UPR) can trigger programmed cell death. Studies in cancer cell lines demonstrated that the intracellular accumulation of TRAIL receptor-2 (TRAIL-R2) and the subsequent activation of caspase-8 contribute significantly to apoptosis indu...

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Detalles Bibliográficos
Autores principales: Hagenlocher, Cathrin, Siebert, Robin, Taschke, Bruno, Wieske, Senait, Hausser, Angelika, Rehm, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786928/
https://www.ncbi.nlm.nih.gov/pubmed/35075141
http://dx.doi.org/10.1038/s41420-022-00830-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786928/
https://www.ncbi.nlm.nih.gov/pubmed/35075141
http://dx.doi.org/10.1038/s41420-022-00830-y

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