Transmembrane Helices Are an Over-Presented and Evolutionarily Conserved Source of Major Histocompatibility Complex Class I and II Epitopes

Cytolytic T cell responses are predicted to be biased towards membrane proteins. The peptide-binding grooves of most alleles of histocompatibility complex class I (MHC-I) are relatively hydrophobic, therefore peptide fragments derived from human transmembrane helices (TMHs) are predicted to be prese...

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Detalles Bibliográficos
Autores principales: Bilderbeek, Richèl J. C., Baranov, Maksim V., van den Bogaart, Geert, Bianchi, Frans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787072/
https://www.ncbi.nlm.nih.gov/pubmed/35087515
http://dx.doi.org/10.3389/fimmu.2021.763044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787072/
https://www.ncbi.nlm.nih.gov/pubmed/35087515
http://dx.doi.org/10.3389/fimmu.2021.763044

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