The Interplay Between Epigenetic Regulation and CD8(+) T Cell Differentiation/Exhaustion for T Cell Immunotherapy

Effective immunotherapy treats cancers by eradicating tumourigenic cells by activated tumour antigen-specific and bystander CD8(+) T-cells. However, T-cells can gradually lose cytotoxicity in the tumour microenvironment, known as exhaustion. Recently, DNA methylation, histone modification, and chrom...

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Detalles Bibliográficos
Autores principales: Wong, Wai Ki, Yin, Bohan, Lam, Ching Ying Katherine, Huang, Yingying, Yan, Jiaxiang, Tan, Zhiwu, Wong, Siu Hong Dexter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787221/
https://www.ncbi.nlm.nih.gov/pubmed/35087832
http://dx.doi.org/10.3389/fcell.2021.783227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787221/
https://www.ncbi.nlm.nih.gov/pubmed/35087832
http://dx.doi.org/10.3389/fcell.2021.783227

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