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The Interplay Between Epigenetic Regulation and CD8(+) T Cell Differentiation/Exhaustion for T Cell Immunotherapy
Effective immunotherapy treats cancers by eradicating tumourigenic cells by activated tumour antigen-specific and bystander CD8(+) T-cells. However, T-cells can gradually lose cytotoxicity in the tumour microenvironment, known as exhaustion. Recently, DNA methylation, histone modification, and chrom...
Autores principales: | Wong, Wai Ki, Yin, Bohan, Lam, Ching Ying Katherine, Huang, Yingying, Yan, Jiaxiang, Tan, Zhiwu, Wong, Siu Hong Dexter |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787221/ https://www.ncbi.nlm.nih.gov/pubmed/35087832 http://dx.doi.org/10.3389/fcell.2021.783227 |
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