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Pharmacological Targeting of STING-Dependent IL-6 Production in Cancer Cells

Activation of the STING pathway upon genotoxic treatment of cancer cells has been shown to lead to anti-tumoral effects, mediated through the acute production of interferon (IFN)-β. Conversely, the pathway also correlates with the expression of NF-κB-driven pro-tumorigenic genes, but these associati...

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Detalles Bibliográficos
Autores principales: Al-Asmari, Sumaiah S., Rajapakse, Aleksandra, Ullah, Tomalika R., Pépin, Geneviève, Croft, Laura V., Gantier, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787270/
https://www.ncbi.nlm.nih.gov/pubmed/35087822
http://dx.doi.org/10.3389/fcell.2021.709618