Disruption of Active Trans-Sialidase Genes Impairs Egress from Mammalian Host Cells and Generates Highly Attenuated Trypanosoma cruzi Parasites

Trans-sialidases (TS) are unusual enzymes present on the surface of Trypanosoma cruzi, the causative agent of Chagas disease. Encoded by the largest gene family in the T. cruzi genome, only few members of the TS family have catalytic activity. Active trans-sialidases (aTS) are responsible for transf...

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Detalles Bibliográficos
Autores principales: Burle-Caldas, Gabriela de A., dos Santos, Nailma S. A., de Castro, Júlia T., Mugge, Fernanda L. B., Grazielle-Silva, Viviane, Oliveira, Antônio Edson R., Pereira, Milton C. A., Reis-Cunha, João Luís, dos Santos, Anderson Coqueiro, Gomes, Dawidson Assis, Bartholomeu, Daniella C., Moretti, Nilmar S., Schenkman, Sergio, Gazzinelli, Ricardo T., Teixeira, Santuza M. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787462/
https://www.ncbi.nlm.nih.gov/pubmed/35073735
http://dx.doi.org/10.1128/mbio.03478-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787462/
https://www.ncbi.nlm.nih.gov/pubmed/35073735
http://dx.doi.org/10.1128/mbio.03478-21

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