Cargando…

Disruption of Active Trans-Sialidase Genes Impairs Egress from Mammalian Host Cells and Generates Highly Attenuated Trypanosoma cruzi Parasites

Trans-sialidases (TS) are unusual enzymes present on the surface of Trypanosoma cruzi, the causative agent of Chagas disease. Encoded by the largest gene family in the T. cruzi genome, only few members of the TS family have catalytic activity. Active trans-sialidases (aTS) are responsible for transf...

Descripción completa

Detalles Bibliográficos
Autores principales:	Burle-Caldas, Gabriela de A., dos Santos, Nailma S. A., de Castro, Júlia T., Mugge, Fernanda L. B., Grazielle-Silva, Viviane, Oliveira, Antônio Edson R., Pereira, Milton C. A., Reis-Cunha, João Luís, dos Santos, Anderson Coqueiro, Gomes, Dawidson Assis, Bartholomeu, Daniella C., Moretti, Nilmar S., Schenkman, Sergio, Gazzinelli, Ricardo T., Teixeira, Santuza M. R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787462/ https://www.ncbi.nlm.nih.gov/pubmed/35073735 http://dx.doi.org/10.1128/mbio.03478-21

Ejemplares similares

Genomic Analyses, Gene Expression and Antigenic Profile of the Trans-Sialidase Superfamily of Trypanosoma cruzi Reveal an Undetected Level of Complexity
por: Freitas, Leandro M., et al.
Publicado: (2011)

Disruption of the inositol phosphorylceramide synthase gene affects Trypanosoma cruzi differentiation and infection capacity
por: Dos Santos, Nailma S A, et al.
Publicado: (2023)

Disruption of multiple copies of the Prostaglandin F2alpha synthase gene affects oxidative stress response and infectivity in Trypanosoma cruzi
por: Santi, Ana Maria Murta, et al.
Publicado: (2022)

Mitochondrial Sirtuin TcSir2rp3 Affects TcSODA Activity and Oxidative Stress Response in Trypanosoma cruzi
por: dos Santos Moura, Leila, et al.
Publicado: (2021)

Genomics and functional genomics in Leishmania and Trypanosoma cruzi: statuses, challenges and perspectives
por: Bartholomeu, Daniella C, et al.
Publicado: (2021)

Trypanosoma cruzi trans-Sialidase as a Potential Vaccine Target Against Chagas Disease
por: da Costa, Kelli Monteiro, et al.
Publicado: (2021)

Comparative transcriptome profiling of virulent and non-virulent Trypanosoma cruzi underlines the role of surface proteins during infection
por: Belew, A. Trey, et al.
Publicado: (2017)

The MASP Family of Trypanosoma cruzi: Changes in Gene Expression and Antigenic Profile during the Acute Phase of Experimental Infection
por: dos Santos, Sara Lopes, et al.
Publicado: (2012)

Down Modulation of Host Immune Response by Amino Acid Repeats Present in a Trypanosoma cruzi Ribosomal Antigen
por: Toro Acevedo, Carlos A., et al.
Publicado: (2017)

Probing the acceptor substrate binding site of Trypanosoma cruzi trans-sialidase with systematically modified substrates and glycoside libraries
por: Harrison, Jennifer A., et al.
Publicado: (2011)

The gene repertoire of the main cysteine protease of Trypanosoma cruzi, cruzipain, reveals four sub-types with distinct active sites
por: Santos, Viviane Corrêa, et al.
Publicado: (2021)

Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins
por: Matutino Bastos, Tanira, et al.
Publicado: (2019)

Draft Genome Sequence of the Protozoan Parasite Leishmania braziliensis Strain BA788, Isolated from a Clinical Case in Bahia State, Brazil
por: Coqueiro-dos-Santos, Anderson, et al.
Publicado: (2022)

Identification of inhibitors for the transmembrane Trypanosoma cruzi eIF2α kinase relevant for parasite proliferation
por: Marcelino, Tiago de Paula, et al.
Publicado: (2023)

A Membrane-bound eIF2 Alpha Kinase Located in Endosomes Is Regulated by Heme and Controls Differentiation and ROS Levels in Trypanosoma cruzi
por: da Silva Augusto, Leonardo, et al.
Publicado: (2015)

A Trypanosoma cruzi zinc finger protein that is implicated in the control of epimastigote-specific gene expression and metacyclogenesis
por: Tavares, Thais S., et al.
Publicado: (2021)

Trypanosoma cruzi iron superoxide dismutases: insights from phylogenetics to chemotherapeutic target assessment
por: Hickson, Jéssica, et al.
Publicado: (2022)

Trypanosoma cruzi genetic diversity: impact on transmission cycles and Chagas disease
por: Zingales, Bianca, et al.
Publicado: (2022)

Whole genome sequencing of Trypanosoma cruzi field isolates reveals extensive genomic variability and complex aneuploidy patterns within TcII DTU
por: Reis-Cunha, João Luís, et al.
Publicado: (2018)

Trypanosoma brucei and Trypanosoma cruzi DNA Mismatch Repair Proteins Act Differently in the Response to DNA Damage Caused by Oxidative Stress
por: Grazielle-Silva, Viviane, et al.
Publicado: (2020)

Insights into the Activity and Specificity of Trypanosoma cruzi trans-Sialidase from Molecular Dynamics Simulations
por: Mitchell, Felicity L., et al.
Publicado: (2013)

Role of Inactive and Active Trypanosoma cruzi Trans-sialidases on T Cell Homing and Secretion of Inflammatory Cytokines
por: Freire-de-Lima, Leonardo, et al.
Publicado: (2017)

Synthesis and Characterization of Sialylated Lactose- and Lactulose-Derived Oligosaccharides by Trypanosoma cruzi Trans-sialidase
por: Pham, Hien T. T., et al.
Publicado: (2019)

Trypanosoma cruzi trans-sialidase and neuraminidase activities can be mediated by the same enzymes
Publicado: (1992)

Role of Trypanosoma cruzi Trans-sialidase on the Escape from Host Immune Surveillance
por: Nardy, Ana F. F. R., et al.
Publicado: (2016)

Chromosomal copy number variation analysis by next generation sequencing confirms ploidy stability in Trypanosoma brucei subspecies
por: Almeida, Laila Viana, et al.
Publicado: (2018)

Identification and Functional Analysis of Trypanosoma cruzi Genes That Encode Proteins of the Glycosylphosphatidylinositol Biosynthetic Pathway
por: Cardoso, Mariana S., et al.
Publicado: (2013)

Identification of Inhibitors to Trypanosoma cruzi Sirtuins Based on Compounds Developed to Human Enzymes
por: Matutino Bastos, Tanira, et al.
Publicado: (2020)

Evasion of the Immune Response by Trypanosoma cruzi during Acute Infection
por: Cardoso, Mariana S., et al.
Publicado: (2016)

Genomic organization and expression profile of the mucin-associated surface protein (masp) family of the human pathogen Trypanosoma cruzi
por: Bartholomeu, Daniella C., et al.
Publicado: (2009)

Inactive trans-Sialidase Expression in iTS-null Trypanosoma cruzi Generates Virulent Trypomastigotes
por: Pascuale, Carla A., et al.
Publicado: (2017)

Trypanosoma cruzi trans-sialidase: enhancement of virulence in a murine model of Chagas' disease
Publicado: (1995)

CD8(+) T-Cell Responses to Trypanosoma cruzi Are Highly Focused on Strain-Variant trans-Sialidase Epitopes
por: Martin, Diana L, et al.
Publicado: (2006)

Interferon-Gamma Promotes Infection of Astrocytes by Trypanosoma cruzi
por: Silva, Rafael Rodrigues, et al.
Publicado: (2015)

A Window to Toxoplasma gondii Egress
por: Caldas, Lucio Ayres, et al.
Publicado: (2018)

Accessing the Variability of Multicopy Genes in Complex Genomes using Unassembled Next-Generation Sequencing Reads: The Case of Trypanosoma cruzi Multigene Families
por: Reis-Cunha, João Luís, et al.
Publicado: (2022)

GCN2-Like Kinase Modulates Stress Granule Formation During Nutritional Stress in Trypanosoma cruzi
por: Malvezzi, Amaranta Muniz, et al.
Publicado: (2020)

Relevance of the Diversity among Members of the Trypanosoma Cruzi Trans-Sialidase Family Analyzed with Camelids Single-Domain Antibodies
por: Ratier, Laura, et al.
Publicado: (2008)

Replacement of Leishmania (Leishmania) infantum Populations in an Endemic Focus of Visceral Leishmaniasis in Brazil
por: Valdivia, Hugo O., et al.
Publicado: (2022)

The Function of Sialidase Revealed by Sialidase Activity Imaging Probe
por: Minami, Akira, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ure03mm37tjd86c7p05i04ch8o