Cargando…
Inhibiting Mycobacterium abscessus Cell Wall Synthesis: Using a Novel Diazabicyclooctane β-Lactamase Inhibitor To Augment β-Lactam Action
Mycobacterium abscessus (Mab) infections are a growing menace to the health of many patients, especially those suffering from structural lung disease and cystic fibrosis. With multidrug resistance a common feature and a growing understanding of peptidoglycan synthesis in Mab, it is advantageous to i...
Autores principales: | Dousa, Khalid M., Nguyen, David C., Kurz, Sebastian G., Taracila, Magdalena A., Bethel, Christopher R., Schinabeck, William, Kreiswirth, Barry N., Brown, Sheldon T., Boom, W. Henry, Hotchkiss, Richard S., Remy, Kenneth E., Jacono, Frank J., Daley, Charles L., Holland, Steven M., Miller, Alita A., Bonomo, Robert A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787486/ https://www.ncbi.nlm.nih.gov/pubmed/35073757 http://dx.doi.org/10.1128/mbio.03529-21 |
Ejemplares similares
-
1642. A Novel β-lactamase Inhibitor (Durlobactam, DUR) and β-Lactams Enhance Susceptibility Against Multidrug-Resistant (MDR) Mycobacterium abscessus (Mab)
por: Dousa, Khalid M, et al.
Publicado: (2020) -
1390. Durlobactam, a Diazabicyclooctane (DBO) β-lactamase Inhibitor (BLI), Inhibits BlaC and Peptidoglycan (PG) Transpeptidases of Mycobacterium tuberculosis (Mtb): A Novel Approach to Therapeutics for Tuberculosis (TB)?
por: Nguyen, David, et al.
Publicado: (2021) -
1385. Mechanism-Based, In Vitro Inhibition of Mycobacterium abscessus: Assessing β-Lactam Therapy
por: Dousa, Khalid M, et al.
Publicado: (2019) -
2806. The Mechanism of β-Lactam Antibiotic Action: Structural Analysis of Mycobacterium abscessus l,d-Transpeptidases, d,d-Carboxypeptidase and penicillin-binding-proteins binding by imipenem, ceftaroline, and amoxicillin
por: Shin, Eunjeong, et al.
Publicado: (2023) -
Eradicating Pulmonary Mycobacterium abscessus: The Promise of Dual β-Lactam Therapy
por: Alahmdi, Bayan, et al.
Publicado: (2023)