Two-Metal Ion-Dependent Enzymes as Potential Antiviral Targets in Human Herpesviruses

The majority of drug discovery efforts against herpesviruses have focused on nucleoside analogs that target viral DNA polymerases, agents that are associated with dose-limiting toxicity and/or a narrow spectrum of activity. We are pursuing a strategy based on targeting two-metal ion-dependent (TMID)...

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Detalles Bibliográficos
Autores principales: DiScipio, Katherine A., Weerasooriya, Savithri, Szczepaniak, Renata, Hazeen, Akram, Wright, Lee R., Wright, Dennis L., Weller, Sandra K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787488/
https://www.ncbi.nlm.nih.gov/pubmed/35073739
http://dx.doi.org/10.1128/mbio.03226-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787488/
https://www.ncbi.nlm.nih.gov/pubmed/35073739
http://dx.doi.org/10.1128/mbio.03226-21

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