Cargando…

Autofluorescent Organelles Within the Retinal Pigment Epithelium in Human Donor Eyes With and Without Age-Related Macular Degeneration

PURPOSE: Human retinal pigment epithelium (RPE) cells contain lipofuscin, melanolipofuscin, and melanosome organelles that impact clinical autofluorescence (AF) imaging. Here, we quantified the effect of age-related macular degeneration (AMD) on granule count and histologic AF of RPE cell bodies. ME...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bermond, Katharina, von der Emde, Leon, Tarau, Ioana-Sandra, Bourauel, Leonie, Heintzmann, Rainer, Holz, Frank G., Curcio, Christine A., Sloan, Kenneth R., Ach, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2022
Materias:	Retinal Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787573/ https://www.ncbi.nlm.nih.gov/pubmed/35050307 http://dx.doi.org/10.1167/iovs.63.1.23

Ejemplares similares

Autofluorescent Granules of the Human Retinal Pigment Epithelium: Phenotypes, Intracellular Distribution, and Age-Related Topography
por: Bermond, Katharina, et al.
Publicado: (2020)

Histologic Cell Shape Descriptors for the Retinal Pigment Epithelium in Age-Related Macular Degeneration: A Comparison to Unaffected Eyes
por: von der Emde, Leon, et al.
Publicado: (2022)

Characteristics of normal human retinal pigment epithelium cells with extremes of autofluorescence or intracellular granule count
por: Bermond, Katharina, et al.
Publicado: (2021)

Prolonged Lifetimes of Histologic Autofluorescence in Ectopic Retinal Pigment Epithelium in Age-Related Macular Degeneration
por: Simon, Rowena, et al.
Publicado: (2022)

The Cytoskeleton of the Retinal Pigment Epithelium: from Normal Aging to Age-Related Macular Degeneration
por: Tarau, Ioana-Sandra, et al.
Publicado: (2019)

Quantifying Retinal Pigment Epithelium Dysmorphia and Loss of Histologic Autofluorescence in Age-Related Macular Degeneration
por: Gambril, J. Alan, et al.
Publicado: (2019)

Quantitative Fundus Autofluorescence: Advanced Analysis Tools
por: Kleefeldt, Nikolai, et al.
Publicado: (2020)

Retinal pigment epithelium hyperplasia overlying pigment epithelial detachment in age-related macular degeneration can masquerade as neovascularization on optical coherence tomography angiography
por: Chen, Ling, et al.
Publicado: (2018)

Formation of Lipofuscin-Like Autofluorescent Granules in the Retinal Pigment Epithelium Requires Lysosome Dysfunction
por: Escrevente, Cristina, et al.
Publicado: (2021)

Ex Vivo Hyperspectral Autofluorescence Imaging and Localization of Fluorophores in Human Eyes with Age-Related Macular Degeneration
por: Mohammed, Taariq, et al.
Publicado: (2018)

Prospective PED-study of intravitreal aflibercept for refractory vascularized pigment epithelium detachment due to age-related macular degeneration: morphologic characteristics of non-responders in optical coherence tomography
por: Clemens, C. R., et al.
Publicado: (2020)

Activated Retinal Pigment Epithelium, an Optical Coherence Tomography Biomarker for Progression in Age-Related Macular Degeneration
por: Curcio, Christine A., et al.
Publicado: (2017)

Retest variability and patient reliability indices of quantitative fundus autofluorescence in age-related macular degeneration: a MACUSTAR study report
por: von der Emde, Leon, et al.
Publicado: (2023)

Hyperspectral autofluorescence characterization of drusen and sub-RPE deposits in age-related macular degeneration
por: Tong, Yuehong, et al.
Publicado: (2021)

Quantitative Fundus Autofluorescence in Systemic Chloroquine/Hydroxychloroquine Therapy: One Year Follow-Up
por: Radun, Victoria, et al.
Publicado: (2023)

Quantitative Fundus Autofluorescence in Systemic Chloroquine/Hydroxychloroquine Therapy
por: Reichel, Clara, et al.
Publicado: (2020)

Blue-light fundus autofluorescence imaging of pigment epithelial detachments
por: Bindewald-Wittich, Almut, et al.
Publicado: (2022)

Selective Ablation of Megalin in the Retinal Pigment Epithelium Results in Megaophthalmos, Macromelanosome Formation and Severe Retina Degeneration
por: Storm, Tina, et al.
Publicado: (2019)

Quantitative Fundus Autofluorescence in the Developing and Maturing Healthy Eye
por: Pröbster, Carla, et al.
Publicado: (2021)

Spatial and Spectral Characterization of Human Retinal Pigment Epithelium Fluorophore Families by Ex Vivo Hyperspectral Autofluorescence Imaging
por: Ben Ami, Tal, et al.
Publicado: (2016)

Hyper-Reflective Foci in Intermediate Age-Related Macular Degeneration: Spatial Abundance and Impact on Retinal Morphology
por: Saßmannshausen, Marlene, et al.
Publicado: (2023)

Evolution of macular atrophy in eyes with neovascular age-related macular degeneration compared to fellow non-neovascular eyes
por: Blazaki, Styliani, et al.
Publicado: (2023)

Atlas of Human Retinal Pigment Epithelium Organelles Significant for Clinical Imaging
por: Pollreisz, Andreas, et al.
Publicado: (2020)

Near-infrared reflectance imaging of neovascular age-related macular degeneration
por: Theelen, Thomas, et al.
Publicado: (2009)

Hyperreflective Foci, Optical Coherence Tomography Progression Indicators in Age-Related Macular Degeneration, Include Transdifferentiated Retinal Pigment Epithelium
por: Cao, Dongfeng, et al.
Publicado: (2021)

Macular neovascularization lesion type and vision outcomes in neovascular age-related macular degeneration: post hoc analysis of HARBOR
por: Freund, K. Bailey, et al.
Publicado: (2022)

Effects of cataract surgery in Japanese patients with neovascular age-related macular degeneration
por: Nishiguchi, Fumi, et al.
Publicado: (2020)

Individual recurrence intervals after anti-VEGF therapy for age-related macular degeneration
por: Hörster, Robert, et al.
Publicado: (2010)

Prechoroidal cleft thickness correlates with disease activity in neovascular age-related macular degeneration
por: Cozzi, Mariano, et al.
Publicado: (2021)

Modulation of Tmem135 Leads to Retinal Pigmented Epithelium Pathologies in Mice
por: Landowski, Michael, et al.
Publicado: (2020)

Partially Differentiated Neuroretinal Cells Promote Maturation of the Retinal Pigment Epithelium
por: Singh, Deepti, et al.
Publicado: (2020)

Beneficial switch from aflibercept to ranibizumab for the treatment of refractory neovascular age-related macular degeneration
por: Marquis, Liza-Marie, et al.
Publicado: (2020)

Two-year outcome of an observe-and-plan regimen for neovascular age-related macular degeneration treated with Aflibercept
por: Parvin, Parmis, et al.
Publicado: (2017)

Short-term choroidal vascular changes after aflibercept therapy for neovascular age-related macular degeneration
por: Pellegrini, Marco, et al.
Publicado: (2020)

Effects of delay in anti-vascular endothelial growth factor intravitreal injections for neovascular age-related macular degeneration
por: Hanhart, Joel, et al.
Publicado: (2022)

Relationship between the distribution of intra-retinal hyper-reflective foci and the progression of intermediate age-related macular degeneration
por: Verma, Aditya, et al.
Publicado: (2023)

The Role of IRE-XBP1 Pathway in Regulation of Retinal Pigment Epithelium Tight Junctions
por: Ma, Jacey H., et al.
Publicado: (2016)

Association of imaging biomarkers and local activation of complement in aqueous humor of patients with early forms of age-related macular degeneration
por: Sitnilska, Vasilena, et al.
Publicado: (2020)

Cost-minimisation analysis of a treat-and-extend regimen with anti-VEGFs in patients with neovascular age-related macular degeneration
por: Quist, S. W., et al.
Publicado: (2021)

Effects of suspension of anti-vascular endothelial growth factor treatment for neovascular age-related macular degeneration in clinical setting
por: Matsubara, Hisashi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ucc2k027d59kapsccictl8udag