Grabbing the Bull by Both Horns: Bovine Ultralong CDR-H3 Paratopes Enable Engineering of ‘Almost Natural’ Common Light Chain Bispecific Antibodies Suitable For Effector Cell Redirection

A subset of antibodies found in cattle comprises ultralong CDR-H3 regions of up to 70 amino acids. Interestingly, this type of immunoglobulin usually pairs with the single germline VL gene, V30 that is typically very conserved in sequence. In this work, we have engineered ultralong CDR-H3 common lig...

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Detalles Bibliográficos
Autores principales: Klewinghaus, Daniel, Pekar, Lukas, Arras, Paul, Krah, Simon, Valldorf, Bernhard, Kolmar, Harald, Zielonka, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787767/
https://www.ncbi.nlm.nih.gov/pubmed/35087526
http://dx.doi.org/10.3389/fimmu.2021.801368

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787767/
https://www.ncbi.nlm.nih.gov/pubmed/35087526
http://dx.doi.org/10.3389/fimmu.2021.801368

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