Sequential azacitidine and carboplatin induces immune activation in platinum-resistant high-grade serous ovarian cancer cell lines and primes for checkpoint inhibitor immunotherapy

BACKGROUND: Platinum chemoresistance results in high-grade serous ovarian cancer (HGSOC) disease recurrence. Recent treatment advances using checkpoint inhibitor immunotherapy has not benefited platinum-resistant HGSOC. In ovarian cancer, DNA methyltransferase inhibitors (DNMTi) block methylation an...

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Detalles Bibliográficos
Autores principales: Wong-Brown, Michelle W., van der Westhuizen, Andre, Bowden, Nikola A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787901/
https://www.ncbi.nlm.nih.gov/pubmed/35073851
http://dx.doi.org/10.1186/s12885-022-09197-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787901/
https://www.ncbi.nlm.nih.gov/pubmed/35073851
http://dx.doi.org/10.1186/s12885-022-09197-w

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