Regioselective approach to colchiceine tropolone ring functionalization at C(9) and C(10) yielding new anticancer hybrid derivatives containing heterocyclic structural motifs

The influence of base type, temperature, and solvent on regioselective C(9)/C(10) “click” modifications within the tropolone ring of colchiceine (2) is investigated. New ether derivatives of 2, bearing alkyne, azide, vinyl, or halide aryl groups enable assembly of the alkaloid part with heterocycles...

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Detalles Bibliográficos
Autores principales: Pyta, Krystian, Skrzypczak, Natalia, Ruszkowski, Piotr, Bartl, Franz, Przybylski, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788354/
https://www.ncbi.nlm.nih.gov/pubmed/35067138
http://dx.doi.org/10.1080/14756366.2022.2028782

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788354/
https://www.ncbi.nlm.nih.gov/pubmed/35067138
http://dx.doi.org/10.1080/14756366.2022.2028782

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