Pharmacokinetic Developability and Disposition Profiles of Bispecific Antibodies: A Case Study with Two Molecules

Bispecific antibodies (BsAb) that engage multiple pathways are a promising therapeutic strategy to improve and prolong the efficacy of biologics in complex diseases. In the early stages of discovery, BsAbs often exhibit a broad range of pharmacokinetic (PK) behavior. Optimization of the neonatal Fc...

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Detalles Bibliográficos
Autores principales: Datta-Mannan, Amita, Brown, Robin, Key, Stephanie, Cain, Paul, Feng, Yiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788489/
https://www.ncbi.nlm.nih.gov/pubmed/35076469
http://dx.doi.org/10.3390/antib11010002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788489/
https://www.ncbi.nlm.nih.gov/pubmed/35076469
http://dx.doi.org/10.3390/antib11010002

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