Affordable Biocidal Ultraviolet Cured Cuprous Oxide Filled Vat Photopolymerization Resin Nanocomposites with Enhanced Mechanical Properties

In this study, Cuprous Oxide (Cu(2)O), known for its mechanism against bacteria, was used as filler to induce biocidal properties on a common commercial resin stereolithography (SLA) 3D printing resin. The aim was to develop nanocomposites suitable for the SLA process with a low-cost process that mi...

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Autores principales: Petousis, Markos, Vidakis, Nectarios, Velidakis, Emmanuel, Kechagias, John D., David, Constantine N., Papadakis, Stefanos, Mountakis, Nikolaos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788546/
https://www.ncbi.nlm.nih.gov/pubmed/35076448
http://dx.doi.org/10.3390/biomimetics7010012
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author Petousis, Markos
Vidakis, Nectarios
Velidakis, Emmanuel
Kechagias, John D.
David, Constantine N.
Papadakis, Stefanos
Mountakis, Nikolaos
author_facet Petousis, Markos
Vidakis, Nectarios
Velidakis, Emmanuel
Kechagias, John D.
David, Constantine N.
Papadakis, Stefanos
Mountakis, Nikolaos
author_sort Petousis, Markos
collection PubMed
description In this study, Cuprous Oxide (Cu(2)O), known for its mechanism against bacteria, was used as filler to induce biocidal properties on a common commercial resin stereolithography (SLA) 3D printing resin. The aim was to develop nanocomposites suitable for the SLA process with a low-cost process that mimic host defense peptides (HDPs). Such materials have a huge economic and societal influence on the global technological war on illness and exploiting 3D printing characteristics is an additional asset for these materials. Their mechanical performance was also investigated with tensile, flexural, Charpy’s impact, and Vickers microhardness tests. Morphological analysis was performed through scanning electron microscopy (SEM), atomic force microscopy (AFM), and energy-dispersive X-ray spectroscopy (EDS) analysis, while the thermal behavior was studied through Thermogravimetric Analysis (TGA). The antibacterial activity of the fabricated nanocomposites was investigated using a screening agar well diffusion method, for a gram-negative and a gram-positive bacterium. Three-dimensional printed nanocomposites exhibited antibacterial performance in all loadings studied, while their mechanical enhancement was approximately 20% even at low filler loadings, revealing a multi-functional performance and a potential of Cuprous Oxide implementation in SLA resin matrices for engineering and medical applications.
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spelling pubmed-87885462022-01-26 Affordable Biocidal Ultraviolet Cured Cuprous Oxide Filled Vat Photopolymerization Resin Nanocomposites with Enhanced Mechanical Properties Petousis, Markos Vidakis, Nectarios Velidakis, Emmanuel Kechagias, John D. David, Constantine N. Papadakis, Stefanos Mountakis, Nikolaos Biomimetics (Basel) Article In this study, Cuprous Oxide (Cu(2)O), known for its mechanism against bacteria, was used as filler to induce biocidal properties on a common commercial resin stereolithography (SLA) 3D printing resin. The aim was to develop nanocomposites suitable for the SLA process with a low-cost process that mimic host defense peptides (HDPs). Such materials have a huge economic and societal influence on the global technological war on illness and exploiting 3D printing characteristics is an additional asset for these materials. Their mechanical performance was also investigated with tensile, flexural, Charpy’s impact, and Vickers microhardness tests. Morphological analysis was performed through scanning electron microscopy (SEM), atomic force microscopy (AFM), and energy-dispersive X-ray spectroscopy (EDS) analysis, while the thermal behavior was studied through Thermogravimetric Analysis (TGA). The antibacterial activity of the fabricated nanocomposites was investigated using a screening agar well diffusion method, for a gram-negative and a gram-positive bacterium. Three-dimensional printed nanocomposites exhibited antibacterial performance in all loadings studied, while their mechanical enhancement was approximately 20% even at low filler loadings, revealing a multi-functional performance and a potential of Cuprous Oxide implementation in SLA resin matrices for engineering and medical applications. MDPI 2022-01-10 /pmc/articles/PMC8788546/ /pubmed/35076448 http://dx.doi.org/10.3390/biomimetics7010012 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Petousis, Markos
Vidakis, Nectarios
Velidakis, Emmanuel
Kechagias, John D.
David, Constantine N.
Papadakis, Stefanos
Mountakis, Nikolaos
Affordable Biocidal Ultraviolet Cured Cuprous Oxide Filled Vat Photopolymerization Resin Nanocomposites with Enhanced Mechanical Properties
title Affordable Biocidal Ultraviolet Cured Cuprous Oxide Filled Vat Photopolymerization Resin Nanocomposites with Enhanced Mechanical Properties
title_full Affordable Biocidal Ultraviolet Cured Cuprous Oxide Filled Vat Photopolymerization Resin Nanocomposites with Enhanced Mechanical Properties
title_fullStr Affordable Biocidal Ultraviolet Cured Cuprous Oxide Filled Vat Photopolymerization Resin Nanocomposites with Enhanced Mechanical Properties
title_full_unstemmed Affordable Biocidal Ultraviolet Cured Cuprous Oxide Filled Vat Photopolymerization Resin Nanocomposites with Enhanced Mechanical Properties
title_short Affordable Biocidal Ultraviolet Cured Cuprous Oxide Filled Vat Photopolymerization Resin Nanocomposites with Enhanced Mechanical Properties
title_sort affordable biocidal ultraviolet cured cuprous oxide filled vat photopolymerization resin nanocomposites with enhanced mechanical properties
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788546/
https://www.ncbi.nlm.nih.gov/pubmed/35076448
http://dx.doi.org/10.3390/biomimetics7010012
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