Engineering acetyl-CoA supply and ERG9 repression to enhance mevalonate production in Saccharomyces cerevisiae

Mevalonate is a key precursor in isoprenoid biosynthesis and a promising commodity chemical. Although mevalonate is a native metabolite in Saccharomyces cerevisiae, its production is challenged by the relatively low flux toward acetyl-CoA in this yeast. In this study we explore different approaches...

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Detalles Bibliográficos
Autores principales: Wegner, Scott A, Chen, Jhong-Min, Ip, Samantha S, Zhang, Yanfei, Dugar, Deepak, Avalos, José L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Metabolic Engineering and Synthetic Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788843/
https://www.ncbi.nlm.nih.gov/pubmed/34351398
http://dx.doi.org/10.1093/jimb/kuab050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788843/
https://www.ncbi.nlm.nih.gov/pubmed/34351398
http://dx.doi.org/10.1093/jimb/kuab050

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