Coronaviral RNA-methyltransferases: function, structure and inhibition

Coronaviral methyltransferases (MTases), nsp10/16 and nsp14, catalyze the last two steps of viral RNA-cap creation that takes place in cytoplasm. This cap is essential for the stability of viral RNA and, most importantly, for the evasion of innate immune system. Non-capped RNA is recognized by innat...

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Detalles Bibliográficos
Autores principales: Nencka, Radim, Silhan, Jan, Klima, Martin, Otava, Tomas, Kocek, Hugo, Krafcikova, Petra, Boura, Evzen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Critical Reviews and Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789044/
https://www.ncbi.nlm.nih.gov/pubmed/35018474
http://dx.doi.org/10.1093/nar/gkab1279

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789044/
https://www.ncbi.nlm.nih.gov/pubmed/35018474
http://dx.doi.org/10.1093/nar/gkab1279

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