Ribonucleotides embedded in template DNA impair mitochondrial RNA polymerase progression

Human mitochondria lack ribonucleotide excision repair pathways, causing misincorporated ribonucleotides (rNMPs) to remain embedded in the mitochondrial genome. Previous studies have demonstrated that human mitochondrial DNA polymerase γ can bypass a single rNMP, but that longer stretches of rNMPs p...

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Detalles Bibliográficos
Autores principales: Singh, Meenakshi, Posse, Viktor, Peter, Bradley, Falkenberg, Maria, Gustafsson, Claes M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789056/
https://www.ncbi.nlm.nih.gov/pubmed/35018464
http://dx.doi.org/10.1093/nar/gkab1251

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789056/
https://www.ncbi.nlm.nih.gov/pubmed/35018464
http://dx.doi.org/10.1093/nar/gkab1251

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