Modeling Sequence-Space Exploration and Emergence of Epistatic Signals in Protein Evolution

During their evolution, proteins explore sequence space via an interplay between random mutations and phenotypic selection. Here, we build upon recent progress in reconstructing data-driven fitness landscapes for families of homologous proteins, to propose stochastic models of experimental protein e...

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Detalles Bibliográficos
Autores principales: Bisardi, Matteo, Rodriguez-Rivas, Juan, Zamponi, Francesco, Weigt, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Methods
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789065/
https://www.ncbi.nlm.nih.gov/pubmed/34751386
http://dx.doi.org/10.1093/molbev/msab321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789065/
https://www.ncbi.nlm.nih.gov/pubmed/34751386
http://dx.doi.org/10.1093/molbev/msab321

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