Dissection of nanoconfinement and proximity effects on the binding events in DNA origami nanocavity

Both ligand binding and nanocavity can increase the stability of a biomolecular structure. Using mechanical unfolding in optical tweezers, here we found that a DNA origami nanobowl drastically increased the stability of a human telomeric G-quadruplex bound with a pyridostatin (PDS) ligand. Such a st...

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Detalles Bibliográficos
Autores principales: Jonchhe, Sagun, Pandey, Shankar, Beneze, Christian, Emura, Tomoko, Sugiyama, Hiroshi, Endo, Masayuki, Mao, Hanbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789071/
https://www.ncbi.nlm.nih.gov/pubmed/35037040
http://dx.doi.org/10.1093/nar/gkab1298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789071/
https://www.ncbi.nlm.nih.gov/pubmed/35037040
http://dx.doi.org/10.1093/nar/gkab1298

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