Disrupting the Cdk9/Cyclin T1 heterodimer of 7SK snRNP for the Brd4 and AFF1/4 guided reconstitution of active P-TEFb

P-TEFb modulates RNA polymerase II elongation through alternative interaction with negative and positive regulation factors. While inactive P-TEFbs are mainly sequestered in the 7SK snRNP complex in a chromatin-free state, most of its active forms are in complex with its recruitment factors, Brd4 an...

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Detalles Bibliográficos
Autores principales: Zhou, Kai, Zhuang, Songkuan, Liu, Fulong, Chen, Yanheng, Li, You, Wang, Shihui, Li, Yuxuan, Wen, Huixin, Lin, Xiaohua, Wang, Jie, Huang, Yue, He, Cailing, Xu, Nan, Li, Zongshu, Xu, Lang, Zhang, Zixuan, Chen, Lin-Feng, Chen, Ruichuan, Liu, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789079/
https://www.ncbi.nlm.nih.gov/pubmed/34935961
http://dx.doi.org/10.1093/nar/gkab1228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789079/
https://www.ncbi.nlm.nih.gov/pubmed/34935961
http://dx.doi.org/10.1093/nar/gkab1228

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