Systems-level conservation of the proximal TCR signaling network of mice and humans

We exploited traceable gene tagging in primary human T cells to establish the composition and dynamics of seven canonical TCR-induced protein signaling complexes (signalosomes) using affinity purification coupled with mass spectrometry (AP-MS). It unveiled how the LAT adaptor assembles higher-order...

Descripción completa

Detalles Bibliográficos
Autores principales: Nicolas, Philippe, Ollier, Jocelyn, Mori, Daiki, Voisinne, Guillaume, Celis-Gutierrez, Javier, Gregoire, Claude, Perroteau, Jeanne, Vivien, Régine, Camus, Mylène, Burlet-Schiltz, Odile, Gonzalez de Peredo, Anne, Clémenceau, Béatrice, Roncagalli, Romain, Vié, Henri, Malissen, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Technical Advances and Resources
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789201/
https://www.ncbi.nlm.nih.gov/pubmed/35061003
http://dx.doi.org/10.1084/jem.20211295

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789201/
https://www.ncbi.nlm.nih.gov/pubmed/35061003
http://dx.doi.org/10.1084/jem.20211295

Ejemplares similares